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Full schedule of events
THURSDAY, JUNE 5, 2014
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| 1:00 — 1:05 p.m. |
Welcome Remarks
Jeffrey M. Friedman, M.D., Ph.D.
Investigator, Howard Hughes Medical Institute; Marilyn M. Simpson Professor and Head, Laboratory of Molecular Genetics
The Rockefeller University
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| 1:05 — 5:00 p.m. |
Symposium Session I: Leptin Physiology and Pathophysiology
Caspary Auditorium
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1:05 — 1:20 p.m.
(15 minutes) |
Introductory Remarks
Chair: Phillip Gorden, M.D.
Senior Investigator, Diabetes, Endocrinology, and Obesity Branch
National Institute of Diabetes and Digestive and Kidney Diseases
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1:20 — 1:50 p.m.
(30 minutes) |
Lessons From the Treatment of Human Congenital Leptin Deficiency
Sadaf Farooqi, M.D., Ph.D.
Wellcome Trust Senior Clinical Fellow and Professor of Metabolism and Medicine, Department of Clinical Biochemistry
University of Cambridge
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1:50 — 2:20 p.m.
(30 minutes) |
The Physiology of Leptin and the Meaning of Leptin Resistance
Jeffrey S. Flier, M.D.
Caroline Shields Walker Professor of Medicine; Faculty of Medicine Dean
Harvard Medical School
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2:20 — 2:50 p.m.
(30 minutes) |
Treatment of Obesity and Associated Diseases with Leptin Sensitizers
Umut Ozcan, M.D.
Associate in Medicine, Department of Medicine and Endocrinology
Boston Children's Hospital; Associate Professor, Department of Pediatrics
Harvard Medical School
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2:50 — 3:30 p.m.
(40 minutes) |
Break
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3:30 — 4:00 p.m.
(30 minutes) |
A New Biology For Diabetes and the Impact of Leptin
Roger Unger, M.D.
Professor and Touchstone/West Distinguished Chair in Diabetes Research
UT Southwestern Medical Center
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4:00 — 4:30 p.m.
(30 minutes) |
Leptin-targeted Hypothalamic Circuits Control Higher Brain Functions
Tamas L. Horvath, D.V.M., Ph.D.
Jean and David W. Wallace Professor, Comparative Medicine, Neurobiology, Obstetrics, and Gynecology; Chair, Section of Comparative Medicine Yale School of Medicine
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4:30 — 5:00 p.m.
(30 minutes) |
General Discussion
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| 5:00 — 6:00 p.m. |
Reception
Abby Aldrich Rockefeller Lounge
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| 6:00 — 7:30 p.m. |
Leptin at 20: Body Weight Regulation and the Hunger Hormone
Public panel discussion sponsored by The Rockefeller University Council
Caspary Auditorium
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6:00 — 6:05 p.m.
(5 minutes) |
Welcome
Marc Tessier-Lavigne, Ph.D.
President and Carson Family Professor
The Rockefeller University
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6:05 — 6:15 p.m.
(10 minutes) |
Introductory Remarks, providing the context for discussion
Joseph Goldstein, M.D.
Julie and Louis A. Beecherl, Jr. Distinguished Chair in Biomedical Research;
Chairman, Department of Molecular Genetics
UT Southwestern Medical Center
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6:15 — 7:00 p.m.
(45 minutes) |
Panel Discussion
Moderated by Joseph Goldstein, M.D.
Panelists
Jeffrey S. Flier, M.D.
Jeffrey M. Friedman, M.D., Ph.D.
Phillip Gorden, M.D.
Stephen O'Rahilly, M.D.
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7:00 — 7:30 p.m.
(30 minutes) |
Questions from the Audience
Moderated by Joseph Goldstein, M.D.
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FRIDAY, JUNE 6, 2014
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8:30 a.m. —
12:00 p.m.
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Symposium Session II: Leptin and the Neural Circuit Regulating Appetite
Caspary Auditorium
Chair: Jeffrey M. Friedman, M.D., Ph.D.
Investigator, Howard Hughes Medical Institute; Marilyn M. Simpson Professor and Head, Laboratory of Molecular Genetics
The Rockefeller University
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8:30 — 9:00 a.m.
(30 minutes) |
Neural Circuits Controlling Hunger
Scott M. Sternson, Ph.D.
Group Leader, Janelia Farm Research Campus
Howard Hughes Medical Institute
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9:00 — 9:30 a.m.
(30 minutes) |
Leptin Receptor Signaling and Transcriptional Control
Martin Myers, M.D., Ph.D.
Associate Professor of Internal Medicine; Associate Professor of Molecular and Integrative Physiology
University of Michigan Health System
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9:30 — 10:00 a.m.
(30 minutes) |
Unraveling the CNS Pathways Underlying the Effects of Leptin to Regulate Glucose Homeostasis
Joel Elmquist, D.V.M., Ph.D.
Macline Family Distinguished Professorship in Medical Science;
Carl H. Westcott Distinguished Chair in Medical Research
UT Southwestern Medical Center
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10:00 — 10:30 a.m.
(30 minutes) |
Break
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10:30 — 11:00 a.m.
(30 minutes) |
Leptin Sensitivity: A Role for ROS
Sabrina Diano, Ph.D.
Professor of Obstetrics, Gynecology, and Reproductive Sciences; Professor of Comparative Sciences; Professor of Neurobiology; Director, Reproductive Neurosciences Group
Yale University
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11:00 — 11:30 a.m.
(30 minutes) |
Maternal Programming of Hypothalamic Neurocircuits in Control of Energy and Glucose Homeostasis
Jens C. Brüning, M.D.
Director
Max Planck Institute for Neurological Research
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11:30 — 11:40 a.m.
(10 minutes) |
A Story Not About Leptin
Jeffrey M. Friedman, M.D., Ph.D.
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11:40 — 12:00 p.m.
(20 minutes) |
General Discussion
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12:00 — 1:00 p.m.
(60 minutes) |
Lunch Break
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| 1:00 — 3:15 p.m. |
Symposium Session III: Leptin as a Therapeutic
Caspary Auditorium
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1:00 — 1:10 p.m.
(10 minutes) |
Introductory Remarks
Chair: Alexander M. DePaoli, M.D.
Vice President of Translational Research
NGM Biopharmaceuticals;
Senior Endocrinologist
Sansum Diabetes Research Institute
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1:10 — 1:40 p.m.
(30 minutes) |
Leptin's Roles in the Pathogenesis and Treatment of Lipodystrophy
Rebecca J. Brown, M.D., M.H.Sc.
Assistant Clinical Investigator
National Institute of Diabetes and Digestive and Kidney Diseases
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1:40 — 2:10 p.m.
(30 minutes) |
Leptin in Relation to Neuroendocrine Regulation: From the Nucleoside to the Bedside
Christos S. Mantzoros, M.D., Sc.D.
Professor, Department of Medicine
Harvard Medical School;
Chief, Endocrinology
VA Boston Healthcare System;
Director, Human Nutrition Unit, Endocrinology, Diabetes and Metabolism,
Beth Israel Deaconess Medical Center
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2:10 — 2:40 p.m.
(30 minutes) |
Leptin in Translation: Unexpected Lessons
Elif Oral, M.D.
Associate Professor, Internal Medicine; Assistant Professor, Metabolism, Endocrinology and Diabetes Division
University of Michigan Health System
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2:40 — 3:10 p.m.
(30 minutes) |
Unimolecular Combination Therapeutics Promoting Leptin
Matthias H. Tschöp, M.D.
Alexander-von-Humboldt Professor; Chair, Division of Metabolic Diseases
Technische Universität München;
Scientific Director, Helmholtz Diabetes Center
Hemlholtz Zentrum München
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3:10 — 3:15 p.m.
(5 minutes) |
Closing Remarks
Jeffrey M. Friedman, M.D., Ph.D.
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3:15 — 3:45 p.m.
(30 minutes) |
Tea Reception
Abby Aldrich Rockefeller Lounge
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| 3:45 — 5:00 p.m. |
Friday Lecture Series
Human Metabolic Disease: Lessons From Experiments of Nature
Caspary Auditorium
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3:45 — 3:55 p.m.
(10 minutes) |
Introductory Remarks
Jeffrey M. Friedman, M.D., Ph.D.
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3:55 — 4:40 p.m.
(45 minutes) |
Stephen O'Rahilly, M.D.
Co-Director, Institute of Metabolic Research; Director, University of Cambridge Metabolic Research Laboratories; Director, Metabolic Diseases Unit; Professor of Clinical Biochemistry and Medicine
University of Cambridge
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4:40 — 5:00 p.m.
(20 minutes) |
Questions from the Audience
Moderated by Dr. Friedman
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